University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Selenium status and cardiometabolic health: State of the evidence

Stranges, S, Navas-Acien, A, Rayman, MP and Guallar, E (2010) Selenium status and cardiometabolic health: State of the evidence Nutrition, Metabolism and Cardiovascular Diseases, 20 (10). 754 - 760. ISSN 0939-4753

PDF (licence)

Download (32Kb)

Download (170Kb)


Use of selenium enriched foods, supplements and fertilizers has increased markedly in recent years in the US and other Western countries because of the perception that selenium, through anti-oxidant properties of selenoproteins, could potentially reduce the risk of cancer and other chronic diseases. However, concern has been raised recently about possible adverse cardiometabolic effects of high selenium exposure, such as an increased risk of diabetes and hyperlipidemia. Hence, from a public health perspective, the relationship between selenium status and cardio-metabolic health should be clarified in order to help guide consumers in their choices of nutritional supplements and enriched food products. Additional mechanistic evidence is needed to clarify the cardio-metabolic effect of selenium and selenoproteins in human biology. Further epidemiological studies across populations with different selenium status should be conducted to help determine the optimal level of selenium intake in the general population that maximizes the antioxidant and anti-inflammatory benefits of selenium while avoiding potential toxic effects.

Item Type: Article
Additional Information: NOTICE: This is the author’s version of a work that was accepted for publication in Nutrition, Metabolism and Cardiovascular Diseases. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Nutrition, Metabolism and Cardiovascular Diseases, 20(10), December 2010, DOI 10.1016/j.numecd.2010.10.001.
Divisions: Faculty of Health and Medical Sciences > Nutrition and Metabolism
Depositing User: Symplectic Elements
Date Deposited: 27 Mar 2012 13:17
Last Modified: 23 Sep 2013 19:06

Actions (login required)

View Item View Item


Downloads per month over past year

Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800