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Selenium status and cardiometabolic health: State of the evidence

Stranges, S, Navas-Acien, A, Rayman, MP and Guallar, E (2010) Selenium status and cardiometabolic health: State of the evidence NUTR METAB CARDIOVAS, 20 (10). pp. 754-760.

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Abstract

Use of selenium enriched foods, supplements and fertilizers has increased markedly in recent years in the US and other Western countries because of the perception that the anti-oxidant properties of selenium could potentially reduce the risk of cancer and other chronic diseases. However, concern has been raised recently about possible adverse cardiometabolic effects of high selenium exposure, including an increased risk of diabetes and hyperlipidemia with high selenium intake. Hence, from a public health perspective, the relationship between selenium status and cardiometabolic health should be clarified in order to help guide consumers in their choices of nutritional supplements and enriched food products. Additional experimental evidence is needed to provide new insights into the role of selenium and of specific selenoproteins in human biology, especially to clarify the underlying mechanisms linking selenium to chronic disease endpoints. Further epidemiological studies and randomized clinical trials across populations with different selenium status should be conducted to determine the causal effect of selenium on cardiovascular disease and risk factors. Nevertheless, at the present time the widespread use of selenium supplements or other strategies that artificially increase selenium status above the level required for optimal selenoprotein activity is not justified and should not be encouraged

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Nutritional Sciences
Authors :
AuthorsEmailORCID
Stranges, SUNSPECIFIEDUNSPECIFIED
Navas-Acien, AUNSPECIFIEDUNSPECIFIED
Rayman, MPUNSPECIFIEDUNSPECIFIED
Guallar, EUNSPECIFIEDUNSPECIFIED
Date : December 2010
Identification Number : 10.1016/j.numecd.2010.10.001
Uncontrolled Keywords : Selenium, Dietary supplements, Cardiovascular disease, Type 2 diabetes, Blood lipids, Epidemiological studies, Randomized clinical trials, CORONARY-HEART-DISEASE, GLUTATHIONE-PEROXIDASE ACTIVITY, APOLIPOPROTEIN-E RECEPTOR-2, ACUTE MYOCARDIAL-INFARCTION, RANDOMIZED CLINICAL-TRIAL, FOOD-CHAIN SELENIUM, SERUM SELENIUM, ANTIOXIDANT VITAMINS, US ADULTS, CARDIOVASCULAR-DISEASE
Additional Information : Copyright © 2010 Elsevier B.V. All rights reserved. NOTICE: this is the author’s version of a work that was accepted for publication in Nutrition, Metabolism and Cardiovascular Diseases. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Nutrition, Metabolism and Cardiovascular Diseases, 20(10), December 2010, DOI: 10.1016/j.numecd.2010.10.001
Depositing User : Symplectic Elements
Date Deposited : 13 Feb 2013 18:15
Last Modified : 23 Sep 2013 19:06
URI: http://epubs.surrey.ac.uk/id/eprint/184921

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