Systems biology of the metabolism of Mycobacterium tuberculosis
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Beste, DJV and McFadden, J (2010) Systems biology of the metabolism of Mycobacterium tuberculosis Biochemical Society Transactions, 38 (5). 1286 - 1289. ISSN 0300-5127
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Official URL: http://dx.doi.org/10.1042/BST0381286
Abstract
Despite decades of research, many aspects of the biology of Mycobacterium tuberculosis remain unclear, and this is reflected in the antiquated tools available to treat and prevent tuberculosis and consequently this disease remains a serious public health problem. Important discoveries linking the metabolism of M. tuberculosis and pathogenesis has renewed interest in this area of research. Previous experimental studies were limited to the analysis of individual genes or enzymes, whereas recent advances in computational systems biology and high-throughput experimental technologies now allows metabolism to be studied on a genome scale. In the present article, we discuss the progress being made in applying system-level approaches to study the metabolism of this important pathogen.
| Item Type: | Article |
|---|---|
| Additional Information: | This research was originally published in Biochemical Society Transactions. Beste, D. J. V. & McFadden, J. Systems biology of the metabolism of Mycobacterium tuberculosis. Biochemical Society Transactions. 2010; 38: 1286-1289 © Portland Press |
| Uncontrolled Keywords: | high-throughput approach, metabolism, Mycobacterium tuberculosis, pathogenesis, systems biology, tuberculosis, GENE KNOCKOUT SIMULATION, ESCHERICHIA-COLI, CHORISMATE SYNTHASE, RECONSTRUCTION, PERSISTENCE, NETWORK, TARGET, GROWTH, DISCOVERY, VIRULENCE |
| Divisions: | Faculty of Health and Medical Sciences > Microbial and Cellular Sciences |
| ID Code: | 184901 |
| Deposited By: | Symplectic Elements |
| Deposited On: | 03 Feb 2012 14:55 |
| Last Modified: | 16 Feb 2013 15:23 |
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