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In vivo differential effects of fasting, re-feeding, insulin and insulin stimulation time course on insulin signaling pathway components in peripheral tissues.

Agouni, A, Owen, C, Czopek, A, Mody, N and Delibegovic, M (2010) In vivo differential effects of fasting, re-feeding, insulin and insulin stimulation time course on insulin signaling pathway components in peripheral tissues. Biochem Biophys Res Commun, 401 (1). 104 - 111. ISSN 0006-291X

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Abstract

Components of the insulin receptor signaling pathway are probably some of the best studied ones. Even though methods for studying these components are well established, the in vivo effects of different fasting regimens, and the time course of insulin receptor phosphorylation and that of its downstream components in insulin-sensitive peripheral tissues have not been analyzed in detail.

Item Type: Article
Additional Information: NOTICE: this is the author’s version of a work that was accepted for publication in Biochemical and Biophysical Research Communications. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Biochemical and Biophysical Research Communications, 401(1), October 2010, DOI 10.1016/j.bbrc.2010.09.018.
Uncontrolled Keywords: Adipose Tissue, Animals, Blood Glucose, Eating, Fasting, Glycogen Synthase Kinase 3, Insulin, Insulin Receptor Substrate Proteins, Liver, Male, Mice, Mice, Inbred C57BL, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Muscle, Skeletal, Phosphorylation, Proto-Oncogene Proteins c-akt, Receptor, Insulin, Ribosomal Protein S6, Signal Transduction
Divisions: Faculty of Health and Medical Sciences > Biochemistry and Physiology
Depositing User: Symplectic Elements
Date Deposited: 22 Nov 2012 14:18
Last Modified: 23 Sep 2013 19:04
URI: http://epubs.surrey.ac.uk/id/eprint/157950

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