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In vivo dopaminergic and behavioural responses to acute cocaine are altered in adenosine A(2A) receptor knockout mice.

Wells, L, Opacka-Juffry, J, Fisher, D, Ledent, C, Hourani, S and Kitchen, I (2011) In vivo dopaminergic and behavioural responses to acute cocaine are altered in adenosine A(2A) receptor knockout mice. Synapse, 66. pp. 382-390.

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Abstract

Adenosine, acting on A(2A) adenosine receptors, regulates addictive processes induced by drugs of abuse. The present study investigates the role of A(2A) adenosine receptors in neurochemical and behavioural responses to an acute cocaine challenge. Changes in the extracellular levels of dopamine in the nucleus accumbens of mice lacking A(2A) adenosine receptors and wild type littermates after an acute cocaine (20mg/kg) administration were evaluated by in vivo microdialysis studies. Locomotor effects induced by cocaine were measured during the microdialysis procedure. Cocaine-evoked increases in extracellular dopamine were not sustained in mice lacking A(2A) receptors in comparison to wild-type mice (P<0.05). Cocaine administration significantly increased ambulatory activity in both genotypes. However, overall locomotor activity was further increased whilst rest and small local movement measures were significantly attenuated in the A(2A) receptor knockout mice compared to wildtype littermates (P<0.05). Our findings support an important role for adenosine A(2A) receptor in modulating the acute effects of cocaine, as demonstrated by the decrease in cocaine-evoked dopaminergic transmission in the nucleus accumbens. Furthermore, the results support an important antagonistic role of A(2A) R in vivo in regulating psychostimulant-induced hyperlocomotion. Synapse, 2011. © 2011 Wiley-Liss, Inc.

Item Type: Article
Subjects : Pharmacology
Divisions : Faculty of Health and Medical Sciences
Authors :
AuthorsEmailORCID
Wells, LUNSPECIFIEDUNSPECIFIED
Opacka-Juffry, JUNSPECIFIEDUNSPECIFIED
Fisher, DUNSPECIFIEDUNSPECIFIED
Ledent, CUNSPECIFIEDUNSPECIFIED
Hourani, SUNSPECIFIEDUNSPECIFIED
Kitchen, IUNSPECIFIEDUNSPECIFIED
Date : 28 December 2011
Identification Number : 10.1002/syn.21527
Copyright Disclaimer : This is the peer reviewed version of the following article: Wells, L, Opacka-Juffry, J, Fisher, D, Ledent, C, Hourani, S and Kitchen, I (2011) In vivo dopaminergic and behavioural responses to acute cocaine are altered in adenosine A(2A) receptor knockout mice. Synapse, 66. 382 - 390, which has been published in final form at http://dx.doi.org/10.1002/syn.21527. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Additional Information : This is the peer reviewed version of the following article: Wells, L, Opacka-Juffry, J, Fisher, D, Ledent, C, Hourani, S and Kitchen, I (2011) In vivo dopaminergic and behavioural responses to acute cocaine are altered in adenosine A(2A) receptor knockout mice. Synapse, 66. 382 - 390, which has been published in final form at http://dx.doi.org/10.1002/syn.21527. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Depositing User : Symplectic Elements
Date Deposited : 17 Feb 2016 11:46
Last Modified : 17 Feb 2016 11:46
URI: http://epubs.surrey.ac.uk/id/eprint/121738

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